“Keep in <Current Status>” is an inbox cleaning tool. This dynamic Response dropdown option will change depending on the status of your contact. For example, if the contact is in a campaign and you receive an out-of-office reply, you will select Keep in Campaign. If they are already in Cycle and they reply, you will select Keep in Cycle. Same with the other reply actions. You should only use Keep in Campaign for automated replies (NOT actual replies).
All other messages should be dispositioned as Meeting, Follow Up, Cycle, Inactive, or Remove. If you have used the “Keep in Campaign” in error, simply click the “Other” sub inbox, click on the message, select “Response” and choose the appropriate reply action. Remember, “Update” does not send the initial reply but updates the contact and schedules future activity. “Send” does the same thing AND sends the initial reply.